A chemical compound is a substance consisting of two or more different elements chemically bonded together in a fixed proportion by mass.

There are some exceptions to the definition above. Certain crystalline compounds may be treated as chemical compounds despite varying in composition according to the presence or otherwise of elements trapped within the crystal structure. Some compounds regarded as chemically identical may have varying amounts of heavy or light isotopes of the constituent elements, which will make the ratio of elements by mass vary slightly. A compound therefore may not be completely homogenous, but for most purposes in chemistry it can be regarded as such.

Not all molecules are compounds. A diatomic molecule of hydrogen, represented by H2, is homonuclear — made of atoms of only one element, so is not regarded as a compound. Compounds are pure substances that contain two or more elements combined in a definite fixed proportion.